景永奎课题组

导师简介

教育经历：

1979-1983 学士 山东大学药学院药学专业

1985-1988 硕士 沈阳药科大学药理学专业

1988-1991 博士 中国医学科学院中国协和医科大学药理学专业

工作经历：

主任 2019-至今 辽宁省血液肿瘤靶向药物重点实验室

教授 2016-至今 沈阳药科大学无涯学院

副教授 2008-2015 美国西奈山医学院血液肿瘤系

助理教授 2000-2008 美国西奈山医学院血液肿瘤系

研究助理教授 1997-2000 美国西奈山医学院血液肿瘤系

博士后 1993-1997 美国西奈山医学院医学系

博士后 1992-1993 日本东京昭和大学药学院生物化学系

杂志任职:

沈阳药科大学学报副主编

荣誉奖励:

国家特聘教授，国家自然科学基金海外杰出青年基金（B类）获得者

执教课程:

《创新药物的药理学研究策略》 ,主讲 ,沈阳药科大学

社会兼职：

辽宁省药学会药理分会副理事长

基于靶点的药物设计与研究教育部重点实验室第三届学术委员会委员

主要研究方向（导师）

从事于抗肿瘤新药物作用靶点的确认，癌细胞分化诱导剂和凋亡促进剂的寻找及其机制研究。目前的研究方向包括：

1.抗肿瘤创新药物设计和开发。

2.抗白血病药物的临床转化研究。

3.天然化合物的活性筛选和结构修饰。

导师主持、参与的科研项目（含科研获奖等情况）

1.Targeted therapy of acute myeloid leukemia，美国SWCRF癌症研究基金会，主持

2.EVI1和GSTP1在肿瘤细胞中相互作用和靶向药物的研究，国家自然科学基金，主持

3.榄香烯衍生物及制剂抗肿瘤新药开发，企业合作项目，主持 4.辽宁省血液肿瘤靶向药物重点实验室建设，沈阳市科技厅，主持

代表性论文（导师）

1.Juanjuan Yang, Dake Song, Bingqian Li, Xiaoxiao Gao, Yuetong Wang, Xiaohu Li, Changshun Bao, Caijiao Wu, Yu Bao, Samuel Waxman, Guoliang Chen*， Yongkui Jing*. Replacing the tropolonicmethoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance Drug Resistance Updates. 2023;68:100951. (IF:24.3)

2.Yang Qiu, Ying Li, Meng Chai, Huiming Hua, Rui Wang, Samuel Waxman, Yongkui Jing*. The GSK3β/Mcl-1 axis is regulated by both FLT3-ITD and Axl and determines the apoptosis induction abilities of FLT3-ITD inhibitors. Cell Death Discovery. 2023;9;1:44. (IF:7.11)

3.Jingyi Zhang, Yuetong Wang, Chujie Yin, Ping Gong, Zhenwei Zhang, Linxiang Zhao, Samuel Waxman, Yongkui Jing*. Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis. Cell Death & Disease. 2022;13;4;379. (IF:9.001)

4.Yu Han, Huiming Zhang, Shuxiang Wang, Bo Li, Kun Xing, Yuntao Shi, Hongxue Cao, Jian Zhang, Tong Ton, Jie Zang, Lihong Guan, Xiaoxiao Gao, Yuetong Wang, Dan Liu, Min Huang, Yongkui Jing*, Linxiang Zhao*. Optimization of 4,6-Disubstituted Pyrido[3,2-d]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth. Journal of Medicinal Chemistry in press. 2021;64;18;13719~13735.(IF: 7.4)

5.Min Huang, Xiaorui Xie, Ping Gong, Yunfei Wei, Heliang Du, Yuanbo Xu, Qihao Xu, Yongkui Jing*, .Linxiang Zhao*.A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects Eur J Med Chem. 2020;188:111991. (IF: 6.5).

6.Yu Bao, Qihao Xu, Lin Wang, Yunfei Wei, Baichun Hu, Jian Wang, Dan Liu, Linxiang Zhao, Yongkui Jing*. Studying histone deacetylase inhibition and apoptosis induction of psammaplin A monomers with modified thiol group. ACS Medicinal Chemistry Letters.2021;12:39~47. (IF: 4.3)

7.Ping Gong, Kun Li, Ying Li, Dan Liu, Linxiang,Zhao, Yongkui,Jing*. HDAC and Ku70 axis-an effective target for apoptosis induction by a new 2-cyano-3-oxo-1,9-dien glycyrrhetinic acid analogue. Cell Death and Disease. 2018; 9:623. (IF: 8.5)

8.Rui Wang, Ying Li, Ping Gong, Janice Gabrilove, Samuel Waxman, Yongkui Jing*. Arsenic Trioxide and Sorafenib Induce Synthetic Lethality of FLT3-ITD Acute Myeloid Leukemia Cells. Molecular Cancer Therapeutics. 2018, 17:1871~1880. (IF: 6.2 )

9.Rui Wang, Lijuan Xia, Janice Gabrilove, Samuel Waxman, Yongkui Jing*. Sorafenib inhibition of Mcl-1 accelerates ATRA induced apoptosis in differentiation responsive AML cells. Clinical Cancer Research. 2016; 22: 1211~1221. (IF:12.5 )

10.Guyue Liu, Rui Wang, Yuetong Wang, Pengzhan Li, Guisen Zhao, Linxiang,Zhao, Yongkui Jing*. Ethacrynic acid oxadiazole analogs induce apoptosis in malignant hematologic cells through downregulation of Mcl-1 and c-FLIP, which was attenuated by GSTP1-1. Molecular Cancer Therapeutics. 2013; 12:1837~1847. (IF: 6.2 )

11.Rui Wang, Lijuan Xia, Janice Gabrilove, Samuel Waxman, Yongkui Jing*. Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells. Leukemia. 2013; 27:315-324. (IF: 11.5 )

12.Rui Wang, Changda Liu, Lijuan Xia, Guisen Zhao, Janice Gabrilove, Samuel Waxman, Yongkui Jing*. Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase P1-1. Clinical Cancer Research. 2012; 18:6690~6701. (IF:12.5 )

13.Min Lu, Lijuan Xia, Huiming Hua, Yongkui Jing*. Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells. Cancer Research. 2008; 68: 1180~1186. (IF: 12.7)