张申武课题组

导师简介

教育经历：

2018.9 – 2021.6， 博士，药剂学，沈阳药科大学

工作经历：

2021.7. – 2023.6， 师资博士后，中药学，沈阳药科大学

2023.10 – 至今， 青年PI，沈阳药科大学

2023.12 – 至今， 教授，药剂学，沈阳药科大学

杂志任职:

1. 2023 - 至今，Asian Journal of Pharmaceutical Sciences青年编委。

2. 2022 - 至今，Traditional Medicine Research青年编委。

荣誉奖励:

1.辽宁省优秀博士学位论文

2.辽宁省博士后创新创业大赛二等奖

3.沈阳市拔尖人才

4.沈阳市自然学术成果二等奖

主要研究方向（导师）

目前的研究方向包括：

1、小分子纳米组装递药技术；

2、智能响应型凝胶递药系统；

3、新型眼用制剂的设计与开发；

4、肿瘤等铁死亡相关疾病的调控；

导师主持、参与的科研项目（含科研获奖等情况）

1.一体双翼“蝶形”前药纳米组装体用于协同增效肿瘤免疫治疗的研究，国家自然青年科学基金，主持；

2.新型“增效减毒”紫杉醇前药自组装纳米递药系统的构建与评价，中国博士后科学金，主持；

3.基于肿瘤微环境级联释药的前药共组装纳米粒用于逆转肿瘤干细胞耐药的研究，辽宁省自然科学基金，主持；

4.专利技术转让1项，主持；

5.企业技术开发1项，主持

代表性论文（导师）

1. Hongyuan Zhang… Cong Luo*, Shenwu Zhang*; Cong Luo*. Molecularly self-fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke. Nature Communications, 2023 14(1): 255. (IF=16.6, ESI高被引)

2. Ziyue Wang#, Shenwu Zhang#, Zhiqiang Kong, et al. Self-adaptive nanoassembly enabling turn-on hypoxia illumination and periphery/center closed-loop tumor eradication. Cell Reports Medicine, 2023，4: 101014 (IF=14.3)

3. Shenwu Zhang, Jing Wang, et al. Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy. Biomaterials, 2022, 282: 121433. (IF=14.0, ESI高被引)

4. Xinxin Sun… Shenwu Zhang*, Cong Luo*, Self-engineered lipid peroxidation nano-amplifier for ferroptosis-driven antitumor therapy, Chemical Engineering Journal, 2023, 451: 138991. (IF=15.1)

5. Shenwu Zhang, et al. Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy. Acta Pharmaceutica Sinica B, 2021, 11(11): 3636-3647. (IF=14.907)

6. Shenwu Zhang, et al. Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy. Theranostics, 2021, 11(12):6019-6032. (IF=11.6)

7. Xinzhu Shan... Cong Luo, Shenwu Zhang*. Emerging prodrug-engineered nanomedicines for synergistic chemophototherapy. Chemical Engineering Journal, 2022, 136383. (IF=15.1)

8. Yuequan Wang… Zhonggui He, Shenwu Zhang*, Cong Luo*, Jin Sun*. Modularly engineered prodrugnanoassemblies for cancer therapy: Nonpharmacological moiety dominating delivery fates. Nano Research, 2022. (IF=9.9)

9. Chen Wang… Shenwu Zhang*, Cong Luo*. Elaborately engineering of a dual-drug co-assembled nanomedicine for boosting immunogenic cell death and enhancing triple negative breast cancer treatment, Asian Journal of Pharmaceutical Sciences, 2022, 17 (3): 412-424. (IF=10.2)

10. Shenwu Zhang, Xinxin Sun, Ziyue Wang, et al. Molecularly self-engineered nanoamplifier for boosting photodynamic therapy via cascade oxygen elevation and lipid ROS accumulation. ACS Applied Materials & Interfaces, 2022, 14(34): 38497–38505. (IF=9.5)