无涯创新学院
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个人信息:

性别:男  出生年月:1987/05  Email:to-qinbin@163.com

工作经历:

2016/04-今,副教授,沈阳药科大学

教育背景:

2013/10-2016/03,博士后,日本东京大学

2010/09-2013/07,博士,沈阳药科大学

2008/09-2010/07,硕士,沈阳药科大学

2004/09-2008/07,学士,沈阳药科大学

研究方向:

1. 生物催化:生物催化剂的发现及挖掘;通过蛋白质工程提高生物催化剂的活性及选择性;手性药物及其中间体的生物催化合成;活性天然产物的生物转化;

2. 生物合成:天然产物及其生物合成基因簇的挖掘;生物合成基因簇中关键酶的催化机制;萜合成酶及萜类化合物的生物合成;

3. 合成生物学:天然产物及非天然产物的生物合成;

代表性论文:

1. Bin Qin†, YudaiMatsuda†, Takahiro Mori, Masahiro Okada, Zhiyang Quan, Takaaki Mitsuhashi, ToshiyukiWakimoto, Ikuro Abe, An unusual chimeric diterpene synthase from Emericellavariecolor and its functional conversion to a sesterterpene synthase bydomain swapping. Angewandte Chemie International Edition 2016, 55(5), 1658-1661.(†Contributed equally)(封面文章,IF: 11.709

2. Fengyu Qin†, Bin Qin†, Takahiro Mori, Yan Wang, Lingxin Meng, Xin Zhang,Xian Jia, Ikuro Abe, Song You, Engineering of Candida glabrata ketoreductase 1 for asymmetric reduction of α-haloketones.

ACS Catalysis2016, 6 (9), 6135-6140. (†Contributed equally) IF: 9.307

3. Masahiro Okada, Yudai Matsuda,Takaaki Mitsuhashi, Shotaro Hoshino, Takahiro Mori, Kazuya Nakagawa, ZhiyangQuan, Bin Qin, Huiping Zhang,Fumiaki Hayashi, Hiroshi Kawaide, Ikuro Abe,Genome-based discovery of anunprecedented cyclization mode in fungal sesterterpenoids biosynthesis.Journal of the American Chemical Society2016,138 (31), 10011-10018. IF: 13.038

4. Bin Qin, Yuxin Li,Lingxin Meng, Jingping Ouyang, Danni Jin, Lei Wu, Xin Zhang, Xian Jia, SongYou, “Mirror-Image” manipulation of curdione stereoisomer scaffolds by chemicaland biological approaches: development of a sesquiterpenoid library. Journalof Natural Products2015, 78 (2), 272-278.IF: 3.662

5. Bin Qin, Ping Liang,Xian Jia, Xin Zhang, Mao Mu, Xiaoying Wang, Guozhen M...

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